![]() No dosage adjustment is necessary in patients with mild renal impairment.Because of an increase in the exposure of a major metabolite, use of VUMERITY is not recommended in patients with moderate or severe renal impairment USE IN SPECIFIC POPULATIONS Renal Impairment Eosinophilia adverse reactions: A transient increase in mean eosinophil counts was seen during the first 2 months of therapy.dimethyl fumarate, Generic, Multiple Sclerosis, Multiple Sclerosis Agents (oral). Discontinuations due to elevated hepatic transaminases were <1% and were similar in patients treated with dimethyl fumarate or placebo epinephrine injection, USP autoinjector 0.3mg, 0.15mg (Mylan and Teva). PML has occurred in patients taking dimethyl fumarate in the postmarketing setting in the presence of lymphopenia (2 times the ULN.A fatal case of PML occurred in a patient who received dimethyl fumarate for 4 years while enrolled in a clinical trial ![]() PML is an opportunistic viral infection of the brain caused by the JC virus (JCV) that typically only occurs in patients who are immunocompromised, and that usually leads to death or severe disability. Progressive multifocal leukoencephalopathy (PML) has occurred in patients with MS treated with dimethyl fumarate (which has the same active metabolite as VUMERITY).Category: HUMAN PRESCRIPTION DRUG LABEL DEA Schedule: None Marketing Status: Abbreviated New Drug Application Drug Label Information Updated MaIf you are a consumer or patient please visit this version. Progressive Multifocal Leukoencephalopathy NDC Code (s): 0378-0396-14, 0378-0399-91 Packager: Mylan Pharmaceuticals Inc. Patients should be instructed to discontinue VUMERITY and seek immediate medical care should they experience signs and symptoms of anaphylaxis or angioedema Signs and symptoms in patients taking dimethyl fumarate (which has the same active metabolite as VUMERITY) have included difficulty breathing, urticaria, and swelling of the throat and tongue. VUMERITY can cause anaphylaxis and angioedema after the first dose or at any time during treatment.WARNINGS AND PRECAUTIONS Anaphylaxis and Angioedema ![]() Reactions may include anaphylaxis and angioedema National Drug Code (NDC) 00378-0399 Drug Uses Add to Drug List Print Get help with Imprint Code FAQs.
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![]() ![]() Because bad males have a greater tendency to quit the courtship game early, as time goes on and the male has not quit it becomes increasingly probable that he is a “good” male. By delaying mating, the female is able to make some use of this information to achieve a degree of screening. In this way the duration of a male’s courtship effort carries information about his type. It shows that extended courtship can take place, with a good male being willing to court for longer than a bad male and the female delaying mating. The study looks for evolutionarily stable equilibrium behaviours, in which females are doing as well as they can against male behaviour and males are doing as well as they can against female behaviour. ![]() In contrast, a male gets a positive payoff from mating with any female, though his payoff is higher if he is “good” than if he is “bad”. The female gets a positive payoff from mating if the male is a ‘‘good’’ male but a negative payoff if he is ‘‘bad’’, so it is in her interest to gain information about the male’s type with the aim of avoiding mating with a “bad” male. The model assumes that the male is either a ‘‘good’’ or a ‘‘bad’’ type from the female’s point of view, according to his condition or willingness to care for the young after mating. ![]() The mathematical model considers a male and a female in a courtship encounter of unspecified duration, with the game ending when one or other party quits or the female accepts the male as a mate. The research uses game theory to analyse how males and females behave strategically towards each other in the mating game. ![]() ![]() ![]() ![]() In view of the relatively poorer outcomes and risks of severe toxicity, treatment options for older patients with advanced lung cancer remain a subject of discussion. Lung cancer is one of the most common cancers affecting the older population in Japan the median age at diagnosis is 70 years, and one-third of the patients are over 80 years old. The competing interests stated do not alter our adherence to PLOS ONE policies on sharing data and materials. Shoko Noda-Narita, Asuka Kawachi, and Ryo Sadachi, have nothing to disclose. Kan Yonemori reports personal fees from Novartis, Pfizer, Chugai, Eisai, Taiho, and AstraZeneca, outside the submitted work. Takahiro Higashi is employed by the National Cancer Center Japan, which is responsible for operating hospital-based cancer registries nationwide, during the conduct of the study, and the data collection was funded by the internal grant of National Cancer Center. Yasuhiro Fujiwara reports grants and committee member from Japan Agency for Medical Research and Development, and The Ministry of Health Labor and Welfare, Japan, during the conduct of the study, and lecture fee from Astra Zeneca KK, Daiichi Sankyo Co., Ltd, Taiho Pharmaceutical Co., Ltd, Chugai Pharmaceutical Co., Ltd, Novartis Pharma KK, SRL Inc, Bristol-Myers Squibb KK, and Santen Pharmaceutical Co., Ltd, outside the submitted work. Yasushi Goto reports grants and personal fees from Eli Lilly, Chugai, Taiho Pharmaceutical, Pfizer, Novartis, MSD, Guardant Health, and Ono Pharmaceutical, and grants from Kyorin, and Dai-ichi Sankyo, and personal fees from Boehringer Ingelheim, AstraZeneca, and Glaxo Smith Kline, outside the submitted work. Akihiro Hirakawa reports grants and personal fees from Ono Pharmaceutical, and personal fees from Astellas Pharma, AbbVie, Nippon Boehringer Ingelheim, Kissei Pharmaceutical, Pfizer, and Nippon Shinyaku, outside the submitted work. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the manuscript and its Supporting Information.įunding: The authors received no specific funding for this work.Ĭompeting interests: I have read journal’s policy and the authors of this manuscript have the following competing interests: Ayako Okuyama reports grants and other from National Cancer Center in Japan, during the conduct of the study. Received: DecemAccepted: SeptemPublished: September 20, 2021Ĭopyright: © 2021 Noda-Narita et al. PLoS ONE 16(9):Įditor: Wen-Chi Chou, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, TAIWAN (2021) First-line treatment for lung cancer among Japanese older patients: A real-world analysis of hospital-based cancer registry data. Additionally, patients who were aged ≥ 80 years also received systemic chemotherapy, including platinum doublets age did not solely influence regimen selection.Ĭitation: Noda-Narita S, Kawachi A, Okuyama A, Sadachi R, Hirakawa A, Goto Y, et al. Despite recommendations of Japanese guidelines for NSCLC, 60.7% of those who were aged ≥75 years received platinum doublets. In this study, platinum doublets were identified as the most commonly prescribed regimen in those who were aged ≥ 70 years. Carboplatin was commonly prescribed in all age groups only 28.4% of those receiving platinum doublets selected cisplatin. Patients who were aged ≥ 80 years also preferred platinum doublets (35.6%). Among them, platinum doublets were prescribed for 62.7% of the patients who were aged ≥ 70 years, and 60.7% of the patients who were aged ≥ 75 years with no driver mutations in NSCLC only 37.6% of them received single agents. We found that the proportion of patients receiving chemotherapy decreased with age 80.0%, 70.4%, 50.6%, and 30.2% of patients aged 70–74, 75–79, 80–84, and ≥ 85 years, respectively, received chemotherapy. The first-line chemotherapy regimens among 9,737 patients who were diagnosed with advanced lung cancer between January and December 2013, were identified and compared based on age. Data from the survey database of Diagnostic Procedure Combination and hospital-based cancer registries of designated cancer centers nationwide were used. This study aimed to examine the prescribing patterns of first-line chemotherapy according to age in the real-world practice. In clinical practice, physicians are required to decide the treatment based on a lack of enough evidence. In Japan, single agent chemotherapy was recommended for advanced non-small cell lung cancer (NSCLC) for those, who were aged ≥75 years, while the Western guidelines did not recommend a specific regimen. ![]() Aging of the population has led to an increase in the prevalence of cancer among older adults. ![]() ![]() ![]() ![]() A rugged and portable design: We assessed the quality of each portable power station’s exterior materials, as well as any extra features like wheels or handles.Anything heavier than that can be hard to load and unload from a car, or to carry around a house in a blackout. But even so, we set a weight limit at 50 pounds, a heft that one (strong) person or two people could reasonably carry. A maximum weight of 50 pounds: Most portable power stations are too big and heavy for the average person to carry them for long distances on foot.Lower outputs are fine for charging phones and most other electronics, but if you want to charge a few devices at a time (especially if one is a high-powered device like a laptop), you need 100 W or more. An output rating of at least 200 W: To separate the portable power stations from their smaller, less powerful counterparts ( USB power banks and portable laptop chargers) we required each of our main and budget contenders to be rated for at least 200 W, and we wanted the lightweight (under 5 pounds) contenders to be rated for at least 100 W.When it comes to batteries, capacity is king. We made this a requirement for our main picks, and strongly preferred it for our budget and lightweight contenders. (For a variety of reasons, less than 100% of a battery’s designed capacity is actually available for use.) Put another way, that’s like running a 60 W device-such as a MacBook Pro, projector, or tabletop fan-for five hours. A battery capacity of at least 300 Wh: A watt-hour (Wh) is literally the measure of watts per hour, so a battery with a 300 Wh capacity offers the equivalent of running a 300 W device for one hour.This product is not associated with and is not endorsed by Dewalt®. ![]() Note to customers: Dewalt® is a registered trademark of the Dewalt Inductrial Tool Co., used under license.Maximum Output Amp: 2A (USB port), 3A (Barrel jack)įeatures: Short-circuit, under-voltage, over-current protection Output Voltage: 5V DC (USB port), 12V DC (Barrel jack) SYL-2615 Set powered by PA-DD1 adapter and Dewalt ® battery (SYL-2615 Set and Dewalt ® battery are not included)Ĭompatible battery Input voltage: 17 ~ 20V DC Similarly, 2.0Ah (DCB203) 20V MAX battery should be rated as 3,300mAh 12V power bank, or 8,000mAh 5V power bank. When consider the power capacity as 5V power bank, this DCB205 battery is equivalent to a 20,000mAH 5V power bank. Technical talk: When considering the power capacity as a 12V power bank, the 5.0Ah (DCB205) 20V MAX battery should be rated as 8,300mAh. 12V output maximum amperage is increased to 3A. For bullet style smokers such as Weber Smokey Mountain, a 10CFM blower needs to run at less than 30% average time (ambient temp: 40F, set temp 225F). For Kamado style smokers/grills such as Big Green Egg, a 6.5CFM blower only needs to run at less than 5% average time (ambient temp: 40F, set temp: 225F). 50 Hours operating time is based on 2Ah battery, SYL-1615 controller and 6.5CFM blower (5% average blower output). The actual operating time depends on many factors, including the battery capacity, ambient temperature, cooking temperature, blower size and also the fuel burning status. *: 20 Hours operating time is based on 2Ah battery, SYL-2615 controller and 20CFM blower (30% average blower output). They can be used for charging cell phones and/or other USB powered device such as Bluetooth speakers. One of the 5V USB output is rated for 1 amp and the other is rated for 2.1 amp. Typically a fully charged DeWalt ® battery can handle 20 ~ 50 hours average cooking*. It can be used to power the heated jacket, video camera, BBQ smoker controller, and many other devices that requires a 12VDC power supply. The output connection is a standard 5.5/2.1 mm barrel power jack. One male to male power cord for our Auber smoker controller is included. It will convert the DeWalt ® 20V lithium battery into a 12V regular lithium battery power bank (power pack) with one 12V 3A DC** output and two USB 5V DC outputs. If you have DeWalt ® power drill or other power tools that use DeWalt ® 20V Max battery, this unit will allow you to power our charcoal smoker controllers with the same battery. One 3 ft power cable is also included for your convenience, which can be used to power SYL-1615 / SYL-2615 / SYL-3615 BBQ controller directly. This listing includes one 12V & 5V converter / charger for DeWalt ® 20V Battery, DCB091 compatible, for Heated Jacket, Video Camera, BBQ Smoker Controller. ![]() ![]() ![]() Ghost Headband – Automatically obtained during Act 2 – Main Quest: From the Darkness.Sakai Clan Helmet – Automatically obtained during Act 2 – Main Quest: Ghosts from the Past (upgradable).Samurai Clan Helmet – Automatically obtained during Act 1 – Main Quest: The Tale of Lady Masako (upgradable).Ashen Straw Hat – Obtain Ronin Attire during Act 1 – Main Quest: Blood on the Grass and then upgrade it at an armorer.Weathered Straw Hat – Automatically obtained during Act 1 – Main Quest: Blood on the Grass. ![]()
![]() Solving the puzzle would lead to comic that showed a teaser for the upcoming multiplayer feature. The trailer for the DLC had a hidden link to a website that had a map and a puzzle.
![]() ![]() I'll be testing a full 8TB restore here soon once the initial backup set is completed. Restoring works from my testing with various files types and sizes. This would never be a problem once all files are initially backed up, but it is an interesting facet of the this solution's workflow. 9 MB/s puts it over, and the parameter has to be a whole number). This should keep Duplicati happy and support uninterrupted backups during my initial upload set. I have since throttled my uploads to 8 MB/s to keep it under this ceiling. The only thing with Google Drive, is that you can only upload 750GB/Day. I hit exactly 725.4GB before Duplicati started throwing server side errors. However, you do have to own your own domain to use this solution. They currently offer unlimited storage for $12/Month, and they do not enforce the 5 user minimum. I tried both, and I ended up using Duplicati and a cloud based solution with encryption, specifically GSuite (Google Drive For Business). I recently came across both Rclone (file syncing ) and Duplicati (true block based backups). Needless to say, it was a bit much, but it worked. I was using a Windows 10 machine to sync my unRAID shares with software called "SyncFolders" and a fleet of USB3 portable drives outside of UNRAID. Once Crashplan was discontinued, I had given up on a native UNRAID cloud backup solution a few months back and went with BackBlaze. Hi, I've been holding off on replying to this topic because I've been in the same boat and have been trying to figure out a viable long term solution, and recently came across one that is working well for me so far. Unless I mount the network shares and do it like that.Īny suggestion on a rock solid reliable app that gives me performance and reliability? Why do you guys use? I need something that will work over scp/ssh/sftp I used ArQ with my Mac mini server and is rock solid, but it won't run on Unraid so I am stuck. Various errors, annoying to even troubleshoot - over scp/ssh/sftpĭuplicati - Good speed / performance but can't restore large 2TB backups - locked database - down right depressed and not willing to troubleshoot further - over scp/ssh/sftp I am stuckĬloudBerry - Horrible speed 2 - 4 Megs upload - I stoped testing due to lack of performance - over scp/ssh/sftpĭuplicacy - Good speed / performance but unreliable restore. So far I tried and failed:ĬrashPlan - I have a 4TB backup that I can't restore with the Unraid app. I don't mean to be a debbie downer on the hard work that is being put into it, but man I will be scared to trust my data with any of these solutions. I am growing a bit depressed to see the state of some backup apps that I tried so far, unbaked, unreliable, down right scary. ![]() ![]() Initially I liked MacJournal better, because you can create a single “entry” and once it’s composed, send it first to one blog and then to the other. Most likely, I will just continue the same way I’ve been doing it, as long as I’m maintaining two mirrored blogs.īoth MarsEdit and MacJournal appear to have strengths and weaknesses relative to what I’m trying to do, which is compose and edit blog entries in a single location, and post them to both WordPress and Livejournal and thus keep two blogs synchronized while I figure out which to stick with. The developer seems to consider LJ a fading platform, and though I don’t know whether user statistics support that impression, my own gut feeling doesn’t contradict it. I wouldn’t rule out taking another look at MarsEdit, but my sense is that enhanced LJ support in that application is not forthcoming. I can blog from any computer with an internet connection. ![]() This method is a bit more “manual” than what I’d hoped for, but it has the advantage of being completely cross-platform (MarsEdit and MacJournal are both Mac-only) and location-independent. In my final appraisal, neither MarsEdit and MacJournal offered any improvement over my existing workflow, which is to make entries in WordPress via the web interface, edit everything to my liking, publish it, then copy-paste the raw HTML into Livejournal’s web interface. Yes, I could use MarsEdit to manage the dual entries in WP and LJ, then manually log into LJ and add the tags, but that was no easier than what I was already doing. MacJournal had other weaknesses that made my decision not just a matter of deciding which tool I preferred to use for the job, but a realization that neither really did it properly. Of the two programs, I thought MarsEdit was overall the better-designed application, but it had the fatal flaw of not supporting tags within Livejournal. I’ll probably edit a link to this follow-up within the earlier post. I now follow-up that earlier post only because I thought the end result of my comparison of the two products might be of interest to some of those reading that earlier post. Both applications claim to support both, so I ran trial versions to see which might work for me. That’s OK, of course - everyone’s welcome here.įor those of you who missed the original post, I compared these two programs as tools to help me manage mirrored blogs on WordPress and Livejournal. ![]() I’m sure those hits come from people who don’t know me, and just happened to google “Mars Edit versus MacJournal” and found that entry. One of the most-viewed entries to this blog is MarsEdit versus MacJournal, a months-old entry which continues to show up among my most-viewed entries every week. ![]() ![]() As for the second point: For years the media and consumers alike have been criticizing EVs that are based on existing gasoline vehicle platforms. Sure, there’s a big-ass screen in the cabin and there’s a frunk up front - plus the whole face looks a bit different - but by and large, the Lightning is familiar. The first point is simple enough: Ford didn’t really weird-ify the Lightning much over the standard F-150. ( Full Disclosure: Ford flew me from Detroit to San Antonio, put me up in a nice hotel, and fed me such high quality food that I bet I could blend it up, strain it, and use the juices as starting fluid to fire up an old Ford 300 straight six). When I arrived at the F-150 Lightning press event in San Antonio, I figured the truck would be quirky like every other EV I’d driven recently, but at the same time I worried that it would be severely compromised given that it’s clearly built on the same architecture as the gasoline F-150. This was not the takeaway I was expecting. These are some great cars I’m mentioning, here, but to most laypeople, they’re kind of weird. It’s the wacky column shifter in the Hyundai, the absurd number of electronic gadgets and storage offerings in the Rivian, it’s the Tesla’s humongous screen in an otherwise oddly understated cabin, it’s the whole vibe of the Honda E. The other key factor is execution, and after driving the truck last week I can say with confidence: Ford nailed it.Īfter having driven machines like the Rivian R1T, Tesla Model 3, Kia EV6, Hyundai Ioniq 5, and Honda E, I’ve gotten used to the “weirdness” that tends to accompany EVs. It’s a key factor behind why I see the launch of the 2022 Ford F-150 Lightning as a major inflection point in automotive history. But this no-nonsense approach is actually the Lightning’s superpower, allowing it to reach the market quickly, remain within a price range that many can afford, and appeal to the masses by being familiar and unintimidating. No, the Lightning is a regular, everyday F-150 with an electric powertrain shoved in, and that’s pretty much it. It’s not styled like something from a sci-fi movie. It doesn’t promise full autonomous driving. If you want to take the truck up some more difficult stuff, a set of all-terrain tires will go a long way-just be wary of how aftermarket tires will affect range.The 2022 Ford F-150 Lightning isn’t a whiz-bang gadget disguised as a truck. Casual enthusiasts and veteran overlanders should have no problem taking the Lightning down their favorite low- to medium-difficulty trails, even without any modifications. While most F-150 Lightning drivers will never take their trucks on any truly challenging paths, it’s nice to know the truck will be able to perform. If it weren’t for the height and shape, you’d think you’re driving a big rally car, not a full-size pickup. There’s gobs of traction thanks to the full-time AWD, and some impressive high-speed dynamics due in part to the truck’s uniquely low center of gravity and near 50-50 weight distribution. While the steering is lacking any sort of feedback, the F-150 EV’s powertrain is eager to blast out of corners with every stab at the go pedal. Ford set up a short rallycross course for us to test out the truck during its first drive event, giving us an opportunity to slide it around without fear of hitting a tree. Though it doesn’t have the same wild ground clearance or suspension travel as its widebody desert-running sibling, the Lightning is no slouch on quicker sections of dirt. You’ll never find yourself having to jab at the accelerator or worry whether the truck is about to jump forward when you’re trying to ease through a path with caution. Even better, the pedal is well-tuned to allow for gradual, measured inputs. Whether you’re trying to climb over a particularly tall rock, fly through a mud pit, or blast out of a gravel corner, it’s more than enough to get you into, through, and out of most situations. That torque comes at exactly zero rpm, as soon as you step on the accelerator pedal. No matter which trim or battery size you go for, the Lightning comes standard with 775 lb-ft of torque. But once you get a taste, you won’t want to go back to internal combustion. It’s tough to appreciate EV off-roading until you actually do it. That makes it easy to listen for changes in traction and wheelslip. The mechanical rear locker is useful for putting power down, while the lack of an engine means crawling happens in total silence. The lack of any sort of widebody panels means it can squeeze through most narrow paths, and a ridiculously tight turning radius allows for some impressive maneuverability. While the hardcore rock-crawling is best saved for those with Raptors, F-150 Lightning owners will be pleasantly surprised with how much their trucks can handle. Mega Power Frunk: The Best F-150 Lightning Feature. ![]() ![]() ![]() These properties make Black Obsidian a very useful stone to keep in your home, workplace, and close to your body to ward off negativity and ensure you are always being true to yourself and to others. Allow you to confront shadows and traumatic events from your past and unlock them if you have yet to notice them.Protect you during contact with guides, or as you receive and send messages in the spiritual world and.Allow you to develop and enhance your psychic abilities.Offer protection to you as you travel the spirit realm.Ground you to the earth, and ground your spirit and body.Siphon out deep insecurities, fears, and problematic behaviors so that you can see them clearly for what they are.Awaken and stimulate the gift of prophecy.In the metaphysical, Obsidian healing properties can: It's used commonly as a powerful shield against negative energy, self-deprecating thoughts, and wayward actions. What are the Black Obsidian metaphysical properties?īlack Obsidian is a guardian stone. The stone's beauty is unsurpassed by even highly reflective, rainbow-colored stones, and the smooth surface makes it an ideal tool for use in “worry stones.” This is helped by the healing properties of Black Obsidian too. Early peoples used Obsidian as tools and weapons, and the sharpness of the stone can be used today for ceremonial cutting, which we'll discuss below. This stone breaks into fragments with sharp, curved edges, which makes it ideal for cutting. It has a Mohs hardness scale rating of 5.5. What Are The Physical Properties Of Obsidian Stone?īlack Obsidian is a smooth, glass-like stone with a shiny, reflective surface. However, Obsidian is not found east of the Mississippi River due to a lack of volcanic activity. ![]() ![]() Most of the Black Obsidian used in jewelry is mined in the United States. It is found all over the world, in both North and South America, and many parts of Asia, including eastern Russia and Japan. Read more about other types of Obsidian stone. Rare colors of Obsidian can be found in blues, reds, yellows, and oranges, and even two colors in a swirled-together, marble-like pattern. However, Obsidian can also be found in greens, tans, and browns. The most common colors of Obsidian stones are black. Black Obsidian is a mineraloid with a rich, deep color and smooth surface that is somewhat mirror-like. This type of rock is called a mineraloid. When this happens, a smooth, volcanic glass-like rock is formed. Sometimes, volcanic lava cools quickly, which does not allow crystals to form. Igneous stones and crystals are formed from cooled volcanic lava, either from active volcanos or from lava in the center of the earth's crust. Obsidian, as you already know, is not a crystal. ![]() |
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